The term "Ozempic face" refers to common side effects associated with the type 2 diabetes medication semaglutide, also known as Ozempic. This medication can lead to facial skin sagging and aging; similar results are associated with using Mounjaro. Individuals experiencing these effects may receive recommendations for lifestyle adjustments or facial fillers to address the symptoms.

At Brilliance Dermatology, we dedicate ourselves to keeping our patients informed on the latest treatments available. We have compiled the following information for our prospective patients’ reference.

Semaglutide and its impact on facial appearance

Semaglutide, the generic name for Ozempic, falls under the category of incretin mimetics. These medications ensure insulin release from the pancreas during high blood glucose levels. Additionally, Ozempic operates as an effective glucagon-like peptide-1 receptor agonist, inducing a sense of fullness and delaying gastric emptying, which aids in calorie reduction.

How Mounjaro Affects Facial Appearance

Mounjaro is similar to Ozempic and has gained popularity recently due to its effectiveness in aiding weight loss. However, its impact on facial appearance is a concern for many individuals considering using the medication. Some studies suggest that Mounjaro can lead to changes in facial appearance, such as reduced facial fat.

Administration and off-label use of Ozempic

Ozempic is administered via injectable pens, with health experts suggesting injections into the thigh, upper arm, or abdomen once per week on the same day. However, many individuals utilize Ozempic off-label to pursue their desired body weight, contributing to a limited supply in the United States due to high demand.

Facial symptoms of Ozempic use

Despite its safety under medical supervision, Ozempic's potential for rapid weight loss can lead to more pronounced changes in facial appearance. Facial fat, which plays a role in skin elasticity and aesthetics, diminishes due to weight loss, contributing to dermatological changes and skin shrinking.

The skin's retraction ability also declines following rapid weight loss, attributed to reduced elastin and collagen levels necessary for structural integrity. Consequently, individuals taking Ozempic may experience symptoms like increased aging signs, loss of facial fat, skin looseness and sagging, a hollowed appearance, and potential lipodystrophy affecting fat accumulation and storage.

Aside from "Ozempic face," Ozempic can cause other side effects ranging from mild to severe, including nausea, vomiting, diarrhea, flatulence, constipation, stomachache, abdominal pain, fatigue, and injection-site reactions. In rare instances, individuals may experience vision changes, kidney issues, gallbladder disease, severe allergic reactions, an elevated thyroid cancer risk, low blood sugar (hypoglycemia), and pancreatitis.

What happens after stopping Ozempic?

Discontinuing Ozempic may lead to weight regain, heightened cravings, absence of side effects, and blood sugar spikes. It takes approximately five weeks after the last dose for the drug to clear from the system.

Preventing facial side effects

For individuals using Ozempic as prescribed, preventing facial side effects might be challenging. However, healthcare providers may suggest strategies such as adjusting dosage, changing medications, maintaining hydration, increasing protein intake, considering dermatological fillers, and adopting lifestyle changes to support a healthy weight.

What is the takeaway?

“Ozempic face" underscores the potential facial changes resulting from Ozempic's impact on weight loss and fat distribution. While Ozempic offers benefits for diabetes and weight management, individuals should weigh its potential side effects against its advantages. Consultation with healthcare professionals remains essential for informed decision-making regarding medication adjustments or alternatives. Open communication with medical experts ensures optimal health and well-being.

Dr. Weitzbuch and the team at Brilliance Dermatology have years of experience in administering Ozempic and managing any side effects that may arise. Contact us today to set up a confidential consultation and learn more about your treatment options.

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